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Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy

Glucose-induced augmented vascular endothelial growth factor (VEGF) production is a key event in diabetic retinopathy. We have previously demonstrated that downregulation of miR-200b increases VEGF, mediating structural and functional changes in the retina in diabetes. However, mechanisms regulating...

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Detalles Bibliográficos
Autores principales: Ruiz, Michael Anthony, Feng, Biao, Chakrabarti, Subrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401764/
https://www.ncbi.nlm.nih.gov/pubmed/25884496
http://dx.doi.org/10.1371/journal.pone.0123987