GRP78/BiP/HSPA5/Dna K is a Universal Therapeutic Target for Human Disease

The chaperone GRP78/Dna K is conserved throughout evolution down to prokaryotes. The GRP78 inhibitor OSU-03012 (AR-12) interacted with sildenafil (Viagra) or tadalafil (Cialis) to rapidly reduce GRP78 levels in eukaryotes and as a single agent reduce Dna K levels in prokaryotes. Similar data with th...

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Detalles Bibliográficos
Autores principales: Booth, Laurence, Roberts, Jane L, Cash, Devin R, Tavallai, Seyedmehrad, Jean, Sophonie, Fidanza, Abigail, Cruz-Luna, Tanya, Siembiba, Paul, Cycon, Kelly A, Cornelissen, Cynthia N, Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402027/
https://www.ncbi.nlm.nih.gov/pubmed/25546329
http://dx.doi.org/10.1002/jcp.24919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402027/
https://www.ncbi.nlm.nih.gov/pubmed/25546329
http://dx.doi.org/10.1002/jcp.24919

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