Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline

The effects of OATP1B1, OAT3, and MRP2 on the pharmacokinetics of eluxadoline, an oral, locally active, opioid receptor agonist/antagonist being developed for treatment of IBS-d were assessed in vivo. Coadministration of a single 200 mg dose of eluxadoline with cyclosporine, and probenecid increased...

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Detalles Bibliográficos
Autores principales: Davenport, J Michael, Covington, Paul, Bonifacio, Laura, McIntyre, Gail, Venitz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Pharmacogenomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402028/
https://www.ncbi.nlm.nih.gov/pubmed/25491493
http://dx.doi.org/10.1002/jcph.442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402028/
https://www.ncbi.nlm.nih.gov/pubmed/25491493
http://dx.doi.org/10.1002/jcph.442

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