Cargando…

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Stimulation of the aryl hydrocarbon receptor (AHR) by xenobiotics is known to affect epidermal differentiation and skin barrier formation. The physiological role of endogenous AHR signaling in keratinocyte differentiation is not known. We used murine and human skin models to address the hypothesis t...

Descripción completa

Detalles Bibliográficos
Autores principales:	van den Bogaard, Ellen, Podolsky, Michael, Smits, Jos, Cui, Xiao, John, Christian, Gowda, Krishne, Desai, Dhimant, Amin, Shantu, Schalkwijk, Joost, Perdew, Gary H., Glick, Adam B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402116/ https://www.ncbi.nlm.nih.gov/pubmed/25602157 http://dx.doi.org/10.1038/jid.2015.6

Ejemplares similares

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
por: Patel, Dhwani, et al.
Publicado: (2023)

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses
por: Muku, Gulsum E., et al.
Publicado: (2017)

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity
por: Muku, Gulsum E., et al.
Publicado: (2019)

Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins
por: Rikken, Gijs, et al.
Publicado: (2022)

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
por: Fang, Zhong-Ze, et al.
Publicado: (2014)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
por: Hubbard, Troy D., et al.
Publicado: (2015)

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
por: Li, Jingxia, et al.
Publicado: (2004)

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
por: Li, Jingxia, et al.
Publicado: (2009)

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia
por: Annageldiyev, Charyguly, et al.
Publicado: (2020)

The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022
por: Perdew, Gary H., et al.
Publicado: (2023)

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
por: Dong, Fangcong, et al.
Publicado: (2020)

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models
por: Smits, Jos P. H., et al.
Publicado: (2017)

Skin microbiota in health and disease: From sequencing to biology
por: Ederveen, Thomas H. A., et al.
Publicado: (2020)

The aryl hydrocarbon receptor at the forefront of host‐microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications
por: van den Bogaard, Ellen H., et al.
Publicado: (2021)

Proteasomal Degradation of Mcl-1 by Maritoclax Induces Apoptosis and Enhances the Efficacy of ABT-737 in Melanoma Cells
por: Pandey, Manoj K., et al.
Publicado: (2013)

The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A
por: Smits, Jos P.H., et al.
Publicado: (2023)

Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration
por: Hahm, Eun-Ryeong, et al.
Publicado: (2012)

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner
por: Varadarajan, Shankar, et al.
Publicado: (2015)

AHR is a master regulator of diverse pathways in endogenous metabolism
por: Granados, Jeffry C., et al.
Publicado: (2022)

Inhibition of Retrograde Transport Limits Polyomavirus Infection In Vivo
por: Maru, Saumya, et al.
Publicado: (2017)

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)
por: Chen, Xiaoling, et al.
Publicado: (2023)

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
por: Morgan, Ethan W, et al.
Publicado: (2023)

A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer
por: Tagaram, Hephzibah Rani S., et al.
Publicado: (2016)

Know your enemy: Unexpected, pervasive and persistent viral and bacterial contamination of primary cell cultures
por: Niehues, Hanna, et al.
Publicado: (2020)

Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development
por: Dinavahi, Saketh S., et al.
Publicado: (2022)

A generic workflow for Single Locus Sequence Typing (SLST) design and subspecies characterization of microbiota
por: Ederveen, Thomas H. A., et al.
Publicado: (2019)

Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain
por: Raup-Konsavage, Wesley M., et al.
Publicado: (2022)

Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
por: Kale, Vijay Pralhad, et al.
Publicado: (2023)

Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome
por: Smits, Jos P. H., et al.
Publicado: (2020)

A novel AhR ligand, 2AI, protects the retina from environmental stress
por: Gutierrez, Mark A., et al.
Publicado: (2016)

Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention
por: Tellez, Carmen S., et al.
Publicado: (2021)

Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer
por: Chen, Kun-Ming, et al.
Publicado: (2021)

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249
por: Weng, Mao-Wen, et al.
Publicado: (2017)

How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function
por: Murray, Iain A., et al.
Publicado: (2020)

Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France
por: Esser, Charlotte, et al.
Publicado: (2018)

Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene
por: Sun, Yuan-Wan, et al.
Publicado: (2017)

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation
por: Nettleford, Shaneice K., et al.
Publicado: (2020)

Glycine‐β‐muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice
por: Jiang, Jie, et al.
Publicado: (2022)

Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models
por: Rikken, Gijs, et al.
Publicado: (2023)

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)
por: Safe, Stephen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9mho981iq1en6phv46fshcbm1b