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Smooth Muscle Specific Overexpression of p22(phox) Potentiates Carotid Artery Wall Thickening in Response to Injury

We hypothesized that transgenic mice overexpressing the p22(phox) subunit of the NADPH oxidase selectively in smooth muscle (Tg(p22smc)) would exhibit an exacerbated response to transluminal carotid injury compared to wild-type mice. To examine the role of reactive oxygen species (ROS) as a mediator...

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Detalles Bibliográficos
Autores principales: Manogue, Michael R., Bennett, Justin R., Holland, Drury S., Choi, Chung-Sik, Drake, Douglas A., Taylor, Mark S., Weber, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402189/
https://www.ncbi.nlm.nih.gov/pubmed/25945151
http://dx.doi.org/10.1155/2015/305686