HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53

BACKGROUND: Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head and neck squamous cell carcinoma, but their role in squamous cell carcinoma of the anal canal (SCCAC) is less well established. The objective of this study was to determine the prognostic...

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Detalles Bibliográficos
Autores principales: Meulendijks, D, Tomasoa, N B, Dewit, L, Smits, P H M, Bakker, R, van Velthuysen, M-L F, Rosenberg, E H, Beijnen, J H, Schellens, J H M, Cats, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402454/
https://www.ncbi.nlm.nih.gov/pubmed/25871546
http://dx.doi.org/10.1038/bjc.2015.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402454/
https://www.ncbi.nlm.nih.gov/pubmed/25871546
http://dx.doi.org/10.1038/bjc.2015.20

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