Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function

Signal transducer and activator of transcription STAT5 is essential for the regulation of proliferation and survival genes. Its activity is tightly regulated through cytokine signaling and is often upregulated in cancer. We showed previously that the deacetylase inhibitor trichostatin A (TSA) inhibi...

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Detalles Bibliográficos
Autores principales: Pinz, Sophia, Unser, Samy, Buob, Dominik, Fischer, Philipp, Jobst, Belinda, Rascle, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402521/
https://www.ncbi.nlm.nih.gov/pubmed/25769527
http://dx.doi.org/10.1093/nar/gkv188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402521/
https://www.ncbi.nlm.nih.gov/pubmed/25769527
http://dx.doi.org/10.1093/nar/gkv188

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