What matters for lac repressor search in vivo—sliding, hopping, intersegment transfer, crowding on DNA or recognition?

We have investigated which aspects of transcription factor DNA interactions are most important to account for the recent in vivo search time measurements for the dimeric lac repressor. We find the best agreement for a sliding model where non-specific binding to DNA is improbable at first contact and...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahmutovic, Anel, Berg, Otto G., Elf, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402528/
https://www.ncbi.nlm.nih.gov/pubmed/25779051
http://dx.doi.org/10.1093/nar/gkv207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402528/
https://www.ncbi.nlm.nih.gov/pubmed/25779051
http://dx.doi.org/10.1093/nar/gkv207

Ejemplares similares