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What matters for lac repressor search in vivo—sliding, hopping, intersegment transfer, crowding on DNA or recognition?
We have investigated which aspects of transcription factor DNA interactions are most important to account for the recent in vivo search time measurements for the dimeric lac repressor. We find the best agreement for a sliding model where non-specific binding to DNA is improbable at first contact and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402528/ https://www.ncbi.nlm.nih.gov/pubmed/25779051 http://dx.doi.org/10.1093/nar/gkv207 |