Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cell...

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Detalles Bibliográficos
Autores principales: Markkanen, Enni, Fischer, Roman, Ledentcova, Marina, Kessler, Benedikt M., Dianov, Grigory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402536/
https://www.ncbi.nlm.nih.gov/pubmed/25800737
http://dx.doi.org/10.1093/nar/gkv222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402536/
https://www.ncbi.nlm.nih.gov/pubmed/25800737
http://dx.doi.org/10.1093/nar/gkv222

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