Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of IFN-I from pDCs. BDCA2 is a pDC-specific receptor th...

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Detalles Bibliográficos
Autores principales: Pellerin, Alex, Otero, Karel, Czerkowicz, Julie M, Kerns, Hannah M, Shapiro, Renée I, Ranger, Ann M, Otipoby, Kevin L, Taylor, Frederick R, Cameron, Thomas O, Viney, Joanne L, Rabah, Dania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403047/
https://www.ncbi.nlm.nih.gov/pubmed/25762615
http://dx.doi.org/10.15252/emmm.201404719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403047/
https://www.ncbi.nlm.nih.gov/pubmed/25762615
http://dx.doi.org/10.15252/emmm.201404719

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