Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

How the brain’s antioxidant defenses adapt to changing demand is incompletely understood. Here we show that synaptic activity is coupled, via the NMDA receptor (NMDAR), to control of the glutathione antioxidant system. This tunes antioxidant capacity to reflect the elevated needs of an active neuron...

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Detalles Bibliográficos
Autores principales: Baxter, Paul S., Bell, Karen F.S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403319/
https://www.ncbi.nlm.nih.gov/pubmed/25854456
http://dx.doi.org/10.1038/ncomms7761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403319/
https://www.ncbi.nlm.nih.gov/pubmed/25854456
http://dx.doi.org/10.1038/ncomms7761

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