Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway

Multiple myeloma (MM) was characterized by frequent mutations in KRAS/NRAS/BRAF within the EGFR pathway that could induce resistance to EGFR inhibitors. We here report that EGFR inhibition solely exhibited moderate inhibition in KRAS/NRAS/BRAF wildtype (triple-WT) MM cells, whilst had no effect in m...

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Detalles Bibliográficos
Autores principales: Chen, Yan, Huang, Ruibin, Ding, Jianghua, Ji, Dexiang, Song, Bing, Yuan, Liya, Chang, Hong, Chen, Guoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403500/
https://www.ncbi.nlm.nih.gov/pubmed/25894462
http://dx.doi.org/10.1038/srep09925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403500/
https://www.ncbi.nlm.nih.gov/pubmed/25894462
http://dx.doi.org/10.1038/srep09925

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