Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett syndrome model mice

Rett syndrome (RTT) is a progressive neurological disorder primarily caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). The heterozygous female brain consists of mosaic of neurons containing both wild-type MeCP2 (MeCP2+) and mutant MeCP2 (MeCP2-). Three-dimensional morpho...

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Detalles Bibliográficos
Autores principales: Rietveld, Leslie, Stuss, David P., McPhee, David, Delaney, Kerry R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403522/
https://www.ncbi.nlm.nih.gov/pubmed/25941473
http://dx.doi.org/10.3389/fncel.2015.00145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403522/
https://www.ncbi.nlm.nih.gov/pubmed/25941473
http://dx.doi.org/10.3389/fncel.2015.00145

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