Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease

While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapi...

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Detalles Bibliográficos
Autores principales: Flynn, William F., Chang, Max W., Tan, Zhiqiang, Oliveira, Glenn, Yuan, Jinyun, Okulicz, Jason F., Torbett, Bruce E., Levy, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404092/
https://www.ncbi.nlm.nih.gov/pubmed/25894830
http://dx.doi.org/10.1371/journal.pcbi.1004249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404092/
https://www.ncbi.nlm.nih.gov/pubmed/25894830
http://dx.doi.org/10.1371/journal.pcbi.1004249

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