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Topoisomerase IIα in Chromosome Instability and Personalized Cancer Therapy
Genome instability is a hallmark of cancer cells. Chromosome instability (CIN), which is often mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome instability. Hypermutations in cancer cells are due to defects in DNA repair genes, but the cause of CIN is still el...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404185/ https://www.ncbi.nlm.nih.gov/pubmed/25328138 http://dx.doi.org/10.1038/onc.2014.332 |