Intermittent Induction of HIF-1α Produces Lasting Effects on Malignant Progression Independent of Its Continued Expression

Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes opposing activities of these factors in cancer biology have been observed. Adding to this complexity is that HIF-1α apparently possesses tumor-supp...

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Detalles Bibliográficos
Autores principales: Choi, Hyunsung, Gillespie, David L., Berg, Shauna, Rice, Christopher, Couldwell, Sandrine, Gu, Jie, Colman, Howard, Jensen, Randy L., Huang, L. Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404255/
https://www.ncbi.nlm.nih.gov/pubmed/25893706
http://dx.doi.org/10.1371/journal.pone.0125125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404255/
https://www.ncbi.nlm.nih.gov/pubmed/25893706
http://dx.doi.org/10.1371/journal.pone.0125125

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