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An approach for determining and measuring network hierarchy applied to comparing the phosphorylome and the regulome
Many biological networks naturally form a hierarchy with a preponderance of downward information flow. In this study, we define a score to quantify the degree of hierarchy in a network and develop a simulated-annealing algorithm to maximize the hierarchical score globally over a network. We apply ou...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404648/ https://www.ncbi.nlm.nih.gov/pubmed/25880651 http://dx.doi.org/10.1186/s13059-015-0624-2 |