Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin

Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated...

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Detalles Bibliográficos
Autores principales: Chan, King Chi, Chan, Lai Sheung, Ip, Joseph Chok Yan, Lo, Carman, Yip, Timothy Tak Chun, Ngan, Roger Kai Cheong, Wong, Ricky Ngok Shun, Lo, Kwok Wai, Ng, Wai Tong, Lee, Anne Wing Mui, Tsao, George Sai Wah, Kahn, Michael, Lung, Maria Li, Mak, Nai Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404684/
https://www.ncbi.nlm.nih.gov/pubmed/25897700
http://dx.doi.org/10.1038/srep09979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404684/
https://www.ncbi.nlm.nih.gov/pubmed/25897700
http://dx.doi.org/10.1038/srep09979

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