Cargando…

Therapeutic targeting of CBP/β-catenin signaling reduces cancer stem-like population and synergistically suppresses growth of EBV-positive nasopharyngeal carcinoma cells with cisplatin

Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, King Chi, Chan, Lai Sheung, Ip, Joseph Chok Yan, Lo, Carman, Yip, Timothy Tak Chun, Ngan, Roger Kai Cheong, Wong, Ricky Ngok Shun, Lo, Kwok Wai, Ng, Wai Tong, Lee, Anne Wing Mui, Tsao, George Sai Wah, Kahn, Michael, Lung, Maria Li, Mak, Nai Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404684/ https://www.ncbi.nlm.nih.gov/pubmed/25897700 http://dx.doi.org/10.1038/srep09979

Ejemplares similares

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation
por: Chan, King Chi, et al.
Publicado: (2013)

Role of miR-96/EVI1/miR-449a Axis in the Nasopharyngeal Carcinoma Cell Migration and Tumor Sphere Formation
por: Chan, Lai-Sheung, et al.
Publicado: (2020)

The CBP/β-Catenin Antagonist, ICG-001, Inhibits Tumor Metastasis via Blocking of the miR-134/ITGB1 Axis-Mediated Cell Adhesion in Nasopharyngeal Carcinoma
por: Chen, Luo, et al.
Publicado: (2022)

miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis
por: Cheung, Chartia Ching-Mei, et al.
Publicado: (2014)

EBV–encoded miRNAs can sensitize nasopharyngeal carcinoma to chemotherapeutic drugs by targeting BRCA1
por: Lung, Raymond Wai‐Ming, et al.
Publicado: (2020)

Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer
por: Ngan, Hoi-Lam, et al.
Publicado: (2018)

MicroRNA profiling study reveals miR-150 in association with metastasis in nasopharyngeal carcinoma
por: Yue, Patrick Ying-Kit, et al.
Publicado: (2017)

MicroRNA-183 suppresses cancer stem-like cell properties in EBV-associated nasopharyngeal carcinoma
por: Cheung, Chartia Ching-Mei, et al.
Publicado: (2016)

EBV‐encoded miRNAs target ATM‐mediated response in nasopharyngeal carcinoma
por: Lung, Raymond W‐M, et al.
Publicado: (2018)

Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells
por: Zhang, Guitao, et al.
Publicado: (2013)

mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma
por: Zhang, Jun, et al.
Publicado: (2019)

CD44+ Cancer Stem-Like Cells in EBV-Associated Nasopharyngeal Carcinoma
por: Lun, Samantha Wei-Man, et al.
Publicado: (2012)

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma
por: Lin, Weitao, et al.
Publicado: (2018)

Epigenomic landscape study reveals molecular subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma
por: Ka-Yue Chow, Larry, et al.
Publicado: (2022)

Identification of a recurrent transforming UBR5–ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma
por: Chung, Grace TY, et al.
Publicado: (2013)

The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells
por: Lung, Hong Lok, et al.
Publicado: (2019)

Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma
por: Chai, Annie Wai Yeeng, et al.
Publicado: (2016)

p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation
por: Man Ip, Carman Ka, et al.
Publicado: (2014)

Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells
por: Tsang, Chi Man, et al.
Publicado: (2014)

Efficient Immortalization of Primary Nasopharyngeal Epithelial Cells for EBV Infection Study
por: Yip, Yim Ling, et al.
Publicado: (2013)

Prognostication of Half-Life Clearance of Plasma EBV DNA in Previously Untreated Non-metastatic Nasopharyngeal Carcinoma Treated With Radical Intensity-Modulated Radiation Therapy
por: Chan, Sik-Kwan, et al.
Publicado: (2020)

Targeting Epstein-Barr Virus in Nasopharyngeal Carcinoma
por: Hau, Pok Man, et al.
Publicado: (2020)

Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells
por: Kwok, Hoi-Hin, et al.
Publicado: (2016)

Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma
por: Lee, Hui Min, et al.
Publicado: (2020)

Dual‐Targeting Peptide‐Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform
por: Zha, Shuai, et al.
Publicado: (2021)

Dietary fiber intake from fresh and preserved food and risk of nasopharyngeal carcinoma: observational evidence from a Chinese population
por: MAI, Zhi-Ming, et al.
Publicado: (2021)

Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma
por: Xu, Meng, et al.
Publicado: (2016)

A physiologically-based pharmacokinetic model of oseltamivir phosphate and its carboxylate metabolite for rats and humans
por: Gao, Guanghua, et al.
Publicado: (2019)

Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA–microRNA regulatory network in nasopharyngeal carcinoma model systems()
por: Szeto, Carol Ying-Ying, et al.
Publicado: (2014)

Solar Ultraviolet Radiation and Vitamin D Deficiency on Epstein-Barr Virus Reactivation: Observational and Genetic Evidence From a Nasopharyngeal Carcinoma-Endemic Population
por: Mai, Zhi-Ming, et al.
Publicado: (2020)

An Exploratory Study of Refining TNM-8 M1 Categories and Prognostic Subgroups Using Plasma EBV DNA for Previously Untreated De Novo Metastatic Nasopharyngeal Carcinoma
por: Chan, Sik-Kwan, et al.
Publicado: (2022)

Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression
por: Keung, Man-Hong, et al.
Publicado: (2016)

Epigenetic Inactivation of Inositol polyphosphate 4-phosphatase B (INPP4B), a Regulator of PI3K/AKT Signaling Pathway in EBV-Associated Nasopharyngeal Carcinoma
por: Yuen, Jessie Wai-Fong, et al.
Publicado: (2014)

Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation
por: Chok, Kenneth S. H., et al.
Publicado: (2011)

The role of Epstein–Barr virus in epithelial malignancies
por: Tsao, Sai-Wah, et al.
Publicado: (2015)

Prognostication of serial post-intensity-modulated radiation therapy undetectable plasma EBV DNA for nasopharyngeal carcinoma
por: Lee, Victor Ho-Fun, et al.
Publicado: (2016)

SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target
por: Emanuel, Oscar, et al.
Publicado: (2021)

Therapeutic evaluation of palbociclib and its compatibility with other chemotherapies for primary and recurrent nasopharyngeal carcinoma
por: Xue, Zhichao, et al.
Publicado: (2020)

Milk Consumption Across Life Periods in Relation to Lower Risk of Nasopharyngeal Carcinoma: A Multicentre Case-Control Study
por: Mai, Zhi-Ming, et al.
Publicado: (2019)

The Therapeutic Potential of Targeting BARF1 in EBV-Associated Malignancies
por: Lo, Angela Kwok-Fung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ef7ad7pelj78r39bqnh71a4egl