Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia

Despite a wide range of studies on neuropsychology in schizophrenia, autobiographical memory (AM) has been scarcely investigated in these patients. Hence, less is known about AM in older patients and hippocampal contribution to autobiographical memories of varying remoteness. Therefore, we investiga...

Descripción completa

Detalles Bibliográficos
Autores principales: Herold, Christina Josefa, Lässer, Marc Montgomery, Schmid, Lena Anna, Seidl, Ulrich, Kong, Li, Fellhauer, Iven, Thomann, Philipp Arthur, Essig, Marco, Schröder, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404739/
https://www.ncbi.nlm.nih.gov/pubmed/25954208
http://dx.doi.org/10.3389/fpsyt.2015.00053
_version_ 1782367545845612544
author Herold, Christina Josefa
Lässer, Marc Montgomery
Schmid, Lena Anna
Seidl, Ulrich
Kong, Li
Fellhauer, Iven
Thomann, Philipp Arthur
Essig, Marco
Schröder, Johannes
author_facet Herold, Christina Josefa
Lässer, Marc Montgomery
Schmid, Lena Anna
Seidl, Ulrich
Kong, Li
Fellhauer, Iven
Thomann, Philipp Arthur
Essig, Marco
Schröder, Johannes
author_sort Herold, Christina Josefa
collection PubMed
description Despite a wide range of studies on neuropsychology in schizophrenia, autobiographical memory (AM) has been scarcely investigated in these patients. Hence, less is known about AM in older patients and hippocampal contribution to autobiographical memories of varying remoteness. Therefore, we investigated hippocampal volume and AM along with important neuropsychological domains in patients with chronic schizophrenia and the respective relationships between these parameters. We compared 25 older patients with chronic schizophrenia to 23 younger patients and an older healthy control group (N = 21) with respect to AM, additional neuropsychological parameters, and hippocampal volume. Personal episodic and semantic memory was investigated using a semi-structured interview. Additional neuropsychological parameters were assessed by using a battery of standard neuropsychological tests. Structural magnetic resonance imaging data were analyzed with an automated region-of-interest procedure. While hippocampal volume reduction and neuropsychological impairment were more pronounced in the older than in the younger patients, both groups showed equivalent reduced AM performance for recent personal episodes. In the patient group, significant correlations between left hippocampal volume and recent autobiographical episodes as well as personal semantic memories arose. Verbal memory and working memory were significantly correlated with right hippocampal volume; executive functions, however, were associated with bilateral hippocampal volumes. These findings underline the complexity of AM and its impairments in the course of schizophrenia in comparison to rather progressive neuropsychological deficits and address the importance of hippocampal contribution.
format Online
Article
Text
id pubmed-4404739
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-44047392015-05-07 Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia Herold, Christina Josefa Lässer, Marc Montgomery Schmid, Lena Anna Seidl, Ulrich Kong, Li Fellhauer, Iven Thomann, Philipp Arthur Essig, Marco Schröder, Johannes Front Psychiatry Psychiatry Despite a wide range of studies on neuropsychology in schizophrenia, autobiographical memory (AM) has been scarcely investigated in these patients. Hence, less is known about AM in older patients and hippocampal contribution to autobiographical memories of varying remoteness. Therefore, we investigated hippocampal volume and AM along with important neuropsychological domains in patients with chronic schizophrenia and the respective relationships between these parameters. We compared 25 older patients with chronic schizophrenia to 23 younger patients and an older healthy control group (N = 21) with respect to AM, additional neuropsychological parameters, and hippocampal volume. Personal episodic and semantic memory was investigated using a semi-structured interview. Additional neuropsychological parameters were assessed by using a battery of standard neuropsychological tests. Structural magnetic resonance imaging data were analyzed with an automated region-of-interest procedure. While hippocampal volume reduction and neuropsychological impairment were more pronounced in the older than in the younger patients, both groups showed equivalent reduced AM performance for recent personal episodes. In the patient group, significant correlations between left hippocampal volume and recent autobiographical episodes as well as personal semantic memories arose. Verbal memory and working memory were significantly correlated with right hippocampal volume; executive functions, however, were associated with bilateral hippocampal volumes. These findings underline the complexity of AM and its impairments in the course of schizophrenia in comparison to rather progressive neuropsychological deficits and address the importance of hippocampal contribution. Frontiers Media S.A. 2015-04-21 /pmc/articles/PMC4404739/ /pubmed/25954208 http://dx.doi.org/10.3389/fpsyt.2015.00053 Text en Copyright © 2015 Herold, Lässer, Schmid, Seidl, Kong, Fellhauer, Thomann, Essig and Schröder. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Herold, Christina Josefa
Lässer, Marc Montgomery
Schmid, Lena Anna
Seidl, Ulrich
Kong, Li
Fellhauer, Iven
Thomann, Philipp Arthur
Essig, Marco
Schröder, Johannes
Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia
title Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia
title_full Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia
title_fullStr Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia
title_full_unstemmed Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia
title_short Neuropsychology, Autobiographical Memory, and Hippocampal Volume in “Younger” and “Older” Patients with Chronic Schizophrenia
title_sort neuropsychology, autobiographical memory, and hippocampal volume in “younger” and “older” patients with chronic schizophrenia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404739/
https://www.ncbi.nlm.nih.gov/pubmed/25954208
http://dx.doi.org/10.3389/fpsyt.2015.00053
work_keys_str_mv AT heroldchristinajosefa neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT lassermarcmontgomery neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT schmidlenaanna neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT seidlulrich neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT kongli neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT fellhaueriven neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT thomannphilipparthur neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT essigmarco neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia
AT schroderjohannes neuropsychologyautobiographicalmemoryandhippocampalvolumeinyoungerandolderpatientswithchronicschizophrenia