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Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation
Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of the inflammatory cytokine, interferon-γ, which is a...
Autores principales: | Dicay, Michael S., Hirota, Christina L., Ronaghan, Natalie J., Peplowski, Michael A., Zaheer, Raza S., Carati, Colin A., MacNaughton, Wallace K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405000/ https://www.ncbi.nlm.nih.gov/pubmed/25793528 http://dx.doi.org/10.1371/journal.pone.0118713 |
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