A p85α–osteopontin axis couples the ICOS receptor to sustained Bcl-6 expression by follicular helper and regulatory T cells

Follicular helper T (T(FH)) cells and follicular regulatory T (T(FR)) cells regulate the quantity and quality of humoral immunity. Although both cell types highly express the co-stimulatory receptor ICOS and require the transcription factor Bcl-6 for their differentiation, the ICOS-dependent pathway...

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Detalles Bibliográficos
Autores principales: Leavenworth, Jianmei W., Verbinnen, Bert, Yin, Jie, Huang, Huicong, Cantor, Harvey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405167/
https://www.ncbi.nlm.nih.gov/pubmed/25436971
http://dx.doi.org/10.1038/ni.3050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405167/
https://www.ncbi.nlm.nih.gov/pubmed/25436971
http://dx.doi.org/10.1038/ni.3050

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