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Regulator of G Protein Signaling 1 Suppresses CXCL12-Mediated Migration and AKT Activation in RPMI 8226 Human Plasmacytoma Cells and Plasmablasts

Migration of plasma cells to the bone marrow is critical factor to humoral immunity and controlled by chemokines. Regulator of G protein signaling 1 (RGS1) is a GTPase-activating protein that controls various crucial functions such as migration. Here, we show that RGS1 controls the chemotactic migra...

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Detalles Bibliográficos
Autores principales: Pak, Hyo-Kyung, Gil, Minchan, Lee, Yoonkyung, Lee, Hyunji, Lee, A-Neum, Roh, Jin, Park, Chan-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405207/
https://www.ncbi.nlm.nih.gov/pubmed/25897806
http://dx.doi.org/10.1371/journal.pone.0124793