Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

Identifying effective therapeutic drug combinations that modulate complex signaling pathways in platelets is central to the advancement of effective anti-thrombotic therapies. However, there is no systems model of the platelet that predicts responses to different inhibitor combinations. We developed...

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Detalles Bibliográficos
Autores principales: Lombardi, Federica, Golla, Kalyan, Fitzpatrick, Darren J., Casey, Fergal P., Moran, Niamh, Shields, Denis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405222/
https://www.ncbi.nlm.nih.gov/pubmed/25875950
http://dx.doi.org/10.1371/journal.pcbi.1004119