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T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses?
Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30–50 % of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405228/ https://www.ncbi.nlm.nih.gov/pubmed/25927019 http://dx.doi.org/10.1007/s40472-014-0019-4 |
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author | Baan, Carla C. de Graav, Gretchen N. Boer, Karin |
author_facet | Baan, Carla C. de Graav, Gretchen N. Boer, Karin |
author_sort | Baan, Carla C. |
collection | PubMed |
description | Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30–50 % of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a specialized T-cell subset has been identified—T follicular helper (Tfh) cells—which support activated B cells via interleukin (IL)-21 after binding to the IL-21 receptor expressed by these B cells. Therefore, neutralizing the IL-21 pathway will selectively inhibit the allogeneic IL-21-driven Tfh- and B-cell functions. However, little is known of the role of Tfh cells in alloreactivity. In this review, we debate the role of Tfh cells in B-cell-mediated allogeneic responses by discussing their mechanisms of actions. In addition, we speculate about the use of agents that intervene in Tfh–B-cell interaction and consequently prevent or treat antibody-mediated rejection in patients after transplantation. |
format | Online Article Text |
id | pubmed-4405228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-44052282015-04-27 T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? Baan, Carla C. de Graav, Gretchen N. Boer, Karin Curr Transplant Rep Immunology (JS Bromberg, Section Editor) Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30–50 % of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a specialized T-cell subset has been identified—T follicular helper (Tfh) cells—which support activated B cells via interleukin (IL)-21 after binding to the IL-21 receptor expressed by these B cells. Therefore, neutralizing the IL-21 pathway will selectively inhibit the allogeneic IL-21-driven Tfh- and B-cell functions. However, little is known of the role of Tfh cells in alloreactivity. In this review, we debate the role of Tfh cells in B-cell-mediated allogeneic responses by discussing their mechanisms of actions. In addition, we speculate about the use of agents that intervene in Tfh–B-cell interaction and consequently prevent or treat antibody-mediated rejection in patients after transplantation. Springer International Publishing 2014-05-23 2014 /pmc/articles/PMC4405228/ /pubmed/25927019 http://dx.doi.org/10.1007/s40472-014-0019-4 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Immunology (JS Bromberg, Section Editor) Baan, Carla C. de Graav, Gretchen N. Boer, Karin T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? |
title | T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? |
title_full | T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? |
title_fullStr | T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? |
title_full_unstemmed | T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? |
title_short | T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? |
title_sort | t follicular helper cells in transplantation: the target to attenuate antibody-mediated allogeneic responses? |
topic | Immunology (JS Bromberg, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405228/ https://www.ncbi.nlm.nih.gov/pubmed/25927019 http://dx.doi.org/10.1007/s40472-014-0019-4 |
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