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Competition between VanU(G) Repressor and VanR(G) Activator Leads to Rheostatic Control of vanG Vancomycin Resistance Operon Expression

Enterococcus faecalis BM4518 is resistant to vancomycin by synthesis of peptidoglycan precursors ending in D-alanyl-D-serine. In the chromosomal vanG locus, transcription of the resistance genes from the P(YG) resistance promoter is inducible and, upstream from these genes, there is an unusual three...

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Detalles Bibliográficos
Autores principales: Depardieu, Florence, Mejean, Vincent, Courvalin, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405338/
https://www.ncbi.nlm.nih.gov/pubmed/25898178
http://dx.doi.org/10.1371/journal.pgen.1005170