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The Influence of Artificially Introduced N-Glycosylation Sites on the In Vitro Activity of Xenopus laevis Erythropoietin

Erythropoietin (EPO), the primary regulator of erythropoiesis, is a heavily glycosylated protein found in humans and several other mammals. Intriguingly, we have previously found that EPO in Xenopus laevis (xlEPO) has no N-glycosylation sites, and cross-reacts with the human EPO (huEPO) receptor des...

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Detalles Bibliográficos
Autores principales: Nagasawa, Kazumichi, Meguro, Mizue, Sato, Kei, Tanizaki, Yuta, Nogawa-Kosaka, Nami, Kato, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405594/
https://www.ncbi.nlm.nih.gov/pubmed/25898205
http://dx.doi.org/10.1371/journal.pone.0124676