Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Despite antiretroviral therapy (ART), HIV-1 persists in a stable latent reservoir(1, 2), primarily in resting memory CD4(+) T cells(3, 4). This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed(5)...

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Detalles Bibliográficos
Autores principales: Deng, Kai, Pertea, Mihaela, Rongvaux, Anthony, Wang, Leyao, Durand, Christine M., Ghiaur, Gabriel, Lai, Jun, McHugh, Holly L., Hao, Haiping, Zhang, Hao, Margolick, Joseph B., Gurer, Cagan, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Deeks, Steven G., Strowig, Till, Kumar, Priti, Siliciano, Janet D., Salzberg, Steven L., Flavell, Richard A., Shan, Liang, Siliciano, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406054/
https://www.ncbi.nlm.nih.gov/pubmed/25561180
http://dx.doi.org/10.1038/nature14053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406054/
https://www.ncbi.nlm.nih.gov/pubmed/25561180
http://dx.doi.org/10.1038/nature14053

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