Cargando…

Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation

Triptolide (TP), one of the major active components of the traditional Chinese herb Tripterygium wilfordii Hook F, and 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of tetrahydrobiopterin (BH4) synthesis, have been reported to have potent anti-inflammatory and immunosuppressive properties. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Weiyun, Yang, Yang, Hu, Zhiying, Ling, Shucai, Fang, Marong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroanatomy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406066/ https://www.ncbi.nlm.nih.gov/pubmed/25954164 http://dx.doi.org/10.3389/fnana.2015.00048

Ejemplares similares

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia
por: Yang, Yang, et al.
Publicado: (2015)

Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia
por: Qin, Yanhua, et al.
Publicado: (2018)

Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia
por: Du, Xiaoxue, et al.
Publicado: (2020)

In Vivo Mapping of Cortical Columnar Networks in the Monkey with Focal Electrical and Optical Stimulation
por: Roe, Anna Wang, et al.
Publicado: (2015)

Three Dimensional-Arterial Spin Labeling Evaluation of Improved Cerebral Perfusion After Limb Remote Ischemic Preconditioning in a Rat Model of Focal Ischemic Stroke
por: Zheng, Tianxiu, et al.
Publicado: (2022)

Neuroprotective Effects of Tauroursodeoxicholic Acid Involves Vascular and Glial Changes in Retinitis Pigmentosa Model
por: Fernández-Sánchez, Laura, et al.
Publicado: (2022)

Comparative neuroprotective effects of Cerebrolysin, dexamethasone, and ascorbic acid on sciatic nerve injury model: Behavioral and histopathological study
por: Elhessy, Heba M., et al.
Publicado: (2023)

Neuroprotective effect of naringin against cerebellar changes in Alzheimer’s disease through modulation of autophagy, oxidative stress and tau expression: An experimental study
por: Hassan, Hend M., et al.
Publicado: (2022)

The Ependymal Region Prevents Glioblastoma From Penetrating Into the Ventricle via a Nonmechanical Force
por: Li, Kaishu, et al.
Publicado: (2021)

The complexity of the calretinin-expressing progenitors in the human cerebral cortex
por: Radonjić, Nevena V., et al.
Publicado: (2014)

Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus
por: van Groen, Thomas, et al.
Publicado: (2021)

Parcellation of the primary cerebral cortices based on local connectivity profiles
por: Li, Qiaojun, et al.
Publicado: (2015)

Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II
por: Coviello, Simona, et al.
Publicado: (2022)

Does Cell Lineage in the Developing Cerebral Cortex Contribute to its Columnar Organization?
por: Costa, Marcos R., et al.
Publicado: (2010)

Automated Individualization of Size-Varying and Touching Neurons in Macaque Cerebral Microscopic Images
por: You, Zhenzhen, et al.
Publicado: (2019)

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway
por: Han, Fei, et al.
Publicado: (2017)

The cortical spectrum: A robust structural continuum in primate cerebral cortex revealed by histological staining and magnetic resonance imaging
por: John, Yohan J., et al.
Publicado: (2022)

Cortical type: a conceptual tool for meaningful biological interpretation of high-throughput gene expression data in the human cerebral cortex
por: Sancha-Velasco, Ariadna, et al.
Publicado: (2023)

The CSF-Contacting Nucleus Receives Anatomical Inputs From the Cerebral Cortex: A Combination of Retrograde Tracing and 3D Reconstruction Study in Rat
por: Song, Si-Yuan, et al.
Publicado: (2020)

Dogs Have the Most Neurons, Though Not the Largest Brain: Trade-Off between Body Mass and Number of Neurons in the Cerebral Cortex of Large Carnivoran Species
por: Jardim-Messeder, Débora, et al.
Publicado: (2017)

HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex
por: Rushmore, Richard Jarrett, et al.
Publicado: (2022)

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum
por: Han, Fei, et al.
Publicado: (2020)

The Brainstem in Emotion: A Review
por: Venkatraman, Anand, et al.
Publicado: (2017)

Neurexin and Neuroligins Maintain the Balance of Ghost and Satellite Boutons at the Drosophila Neuromuscular Junction
por: Guangming, Gan, et al.
Publicado: (2020)

Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons
por: Yang, Cindy F., et al.
Publicado: (2020)

The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis
por: Wang, Yang, et al.
Publicado: (2022)

Distribution Heterogeneity of Muscle Spindles Across Skeletal Muscles of Lower Extremities in C57BL/6 Mice
por: Lian, Wenxi, et al.
Publicado: (2022)

Globus Pallidus Interna in Tourette Syndrome: Decreased Local Activity and Disrupted Functional Connectivity
por: Ji, Gong-Jun, et al.
Publicado: (2016)

Genetic tagging of the adenosine A2A receptor reveals its heterogeneous expression in brain regions
por: Wang, Muran, et al.
Publicado: (2022)

Abnormal prenatal brain development in Chiari II malformation
por: Masse, Olivia, et al.
Publicado: (2023)

Capicua Regulates Dendritic Morphogenesis Through Ets in Hippocampal Neurons in vitro
por: Li, Keqin, et al.
Publicado: (2021)

Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice
por: Yang, Cui-Zhu, et al.
Publicado: (2023)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway
por: Li, Xiao-yu, et al.
Publicado: (2017)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
por: Lan, Tianchi, et al.
Publicado: (2022)

Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial–mesenchymal transition via regulating the PI3K/AKT/mTOR pathway
por: Huang, Yan, et al.
Publicado: (2018)

Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
por: Nair-Roberts, R.G., et al.
Publicado: (2008)

Identification of an immune-responsive mesolimbocortical serotonergic system: Potential role in regulation of emotional behavior
por: Lowry, C.A., et al.
Publicado: (2007)

Development of Parallel Auditory Thalamocortical Pathways for Two Different Behaviors
por: Razak, Khaleel A., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_f9cq5dsiigosrhdjshr6nvktn6