The role of the microbiota in ageing: current state and perspectives

Since the application of high-throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite dif...

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Autores principales: Lynch, Denise B, Jeffery, Ian B, O'Toole, Paul W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406138/
https://www.ncbi.nlm.nih.gov/pubmed/25777986
http://dx.doi.org/10.1002/wsbm.1293
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author Lynch, Denise B
Jeffery, Ian B
O'Toole, Paul W
author_facet Lynch, Denise B
Jeffery, Ian B
O'Toole, Paul W
author_sort Lynch, Denise B
collection PubMed
description Since the application of high-throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite different to the microbial investigations that have preceded it in terms of both the broadness of the area of research and the complexity of the analyses. In this review, we discuss gut microbiota changes observed in ageing in the context of the physiological changes that accompany senescence, examine what correlations can be established or inferred, and we discuss what key questions remain to be answered in the field. © 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc.
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spelling pubmed-44061382015-04-24 The role of the microbiota in ageing: current state and perspectives Lynch, Denise B Jeffery, Ian B O'Toole, Paul W Wiley Interdiscip Rev Syst Biol Med Focus Article Since the application of high-throughput technologies to investigate complex microbial communities, alterations in the human gut microbiota have been associated with an increasing number of diseases and conditions. This field of research has developed into an area of intense study which is quite different to the microbial investigations that have preceded it in terms of both the broadness of the area of research and the complexity of the analyses. In this review, we discuss gut microbiota changes observed in ageing in the context of the physiological changes that accompany senescence, examine what correlations can be established or inferred, and we discuss what key questions remain to be answered in the field. © 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc. John Wiley & Sons, Inc. 2015-05 2015-03-16 /pmc/articles/PMC4406138/ /pubmed/25777986 http://dx.doi.org/10.1002/wsbm.1293 Text en © 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Focus Article
Lynch, Denise B
Jeffery, Ian B
O'Toole, Paul W
The role of the microbiota in ageing: current state and perspectives
title The role of the microbiota in ageing: current state and perspectives
title_full The role of the microbiota in ageing: current state and perspectives
title_fullStr The role of the microbiota in ageing: current state and perspectives
title_full_unstemmed The role of the microbiota in ageing: current state and perspectives
title_short The role of the microbiota in ageing: current state and perspectives
title_sort role of the microbiota in ageing: current state and perspectives
topic Focus Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406138/
https://www.ncbi.nlm.nih.gov/pubmed/25777986
http://dx.doi.org/10.1002/wsbm.1293
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