Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain

BACKGROUND: Neuropathic pain (NP) continues to be challenging to treat due to lack of effective drugs. Accumulating evidence elucidated that glia-mediated inflammatory reactions play a pivotal role in the introduction and development of NP. Besides, activation of the c-Jun N-terminal kinase (JNK)/mo...

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Detalles Bibliográficos
Autores principales: Tang, Jun, Zhu, Chao, Li, Zhi-hong, Liu, Xiao-yu, Sun, Shu-kai, Zhang, Ting, Luo, Zhuo-jing, Zhang, Hui, Li, Wei-yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406216/
https://www.ncbi.nlm.nih.gov/pubmed/25889689
http://dx.doi.org/10.1186/s12974-015-0279-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406216/
https://www.ncbi.nlm.nih.gov/pubmed/25889689
http://dx.doi.org/10.1186/s12974-015-0279-7

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