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Detection of Innate Immune Response Modulating Impurities in Therapeutic Proteins
Therapeutic proteins can contain multiple impurities, some of which are variants of the product, while others are derived from the cell substrate and the manufacturing process. Such impurities, even when present at trace levels, have the potential to activate innate immune cells in peripheral blood...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406594/ https://www.ncbi.nlm.nih.gov/pubmed/25901912 http://dx.doi.org/10.1371/journal.pone.0125078 |