Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression

Telomeric repeat binding factor 2 (TRF2) is essential for telomere maintenance and has been implicated in DNA damage response and aging. Telomere dysfunction induced by TRF2 inhibition can accelerate cellular senescence in human fibroblasts. While previous work has demonstrated that a variety of fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Zhenhua, Feng, Xuyang, Wang, Haoli, Xu, Weiyi, Zhao, Yong, Ma, Wenbin, Jiang, Songshan, Liu, Dan, Huang, Junjiu, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406668/
https://www.ncbi.nlm.nih.gov/pubmed/25753893
http://dx.doi.org/10.1111/acel.12304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406668/
https://www.ncbi.nlm.nih.gov/pubmed/25753893
http://dx.doi.org/10.1111/acel.12304

Ejemplares similares