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Regulation of the p19(Arf)/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice

Brain aging is associated with increased neurodegeneration and reduced neurogenesis. B1/neural stem cells (B1-NSCs) of the mouse subependymal zone (SEZ) support the ongoing production of olfactory bulb interneurons, but their neurogenic potential is progressively reduced as mice age. Although age-re...

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Detalles Bibliográficos
Autores principales: Soriano-Cantón, Raúl, Perez-Villalba, Ana, Morante-Redolat, José Manuel, Marqués-Torrejón, María Ángeles, Pallás, Mercé, Pérez-Sánchez, Francisco, Fariñas, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406674/
https://www.ncbi.nlm.nih.gov/pubmed/25728253
http://dx.doi.org/10.1111/acel.12328