Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity

Maintaining proteostasis is thought to be a key factor in slowed aging. In several growth-restricted models of long-life, we have shown evidence of increased proteostatic mechanisms, suggesting that proteostasis may be a shared characteristic of slowed aging. The Snell dwarf mouse is generated throu...

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Detalles Bibliográficos
Autores principales: Drake, Joshua C, Bruns, Danielle R, Peelor, Frederick F, Biela, Laurie M, Miller, Richard A, Miller, Benjamin F, Hamilton, Karyn L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406676/
https://www.ncbi.nlm.nih.gov/pubmed/25720574
http://dx.doi.org/10.1111/acel.12329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406676/
https://www.ncbi.nlm.nih.gov/pubmed/25720574
http://dx.doi.org/10.1111/acel.12329

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