Accelerated epigenetic aging in Down syndrome

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we u...

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Detalles Bibliográficos
Autores principales: Horvath, Steve, Garagnani, Paolo, Bacalini, Maria Giulia, Pirazzini, Chiara, Salvioli, Stefano, Gentilini, Davide, Di Blasio, Anna Maria, Giuliani, Cristina, Tung, Spencer, Vinters, Harry V, Franceschi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406678/
https://www.ncbi.nlm.nih.gov/pubmed/25678027
http://dx.doi.org/10.1111/acel.12325
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author Horvath, Steve
Garagnani, Paolo
Bacalini, Maria Giulia
Pirazzini, Chiara
Salvioli, Stefano
Gentilini, Davide
Di Blasio, Anna Maria
Giuliani, Cristina
Tung, Spencer
Vinters, Harry V
Franceschi, Claudio
author_facet Horvath, Steve
Garagnani, Paolo
Bacalini, Maria Giulia
Pirazzini, Chiara
Salvioli, Stefano
Gentilini, Davide
Di Blasio, Anna Maria
Giuliani, Cristina
Tung, Spencer
Vinters, Harry V
Franceschi, Claudio
author_sort Horvath, Steve
collection PubMed
description Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(−14)).
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spelling pubmed-44066782015-06-01 Accelerated epigenetic aging in Down syndrome Horvath, Steve Garagnani, Paolo Bacalini, Maria Giulia Pirazzini, Chiara Salvioli, Stefano Gentilini, Davide Di Blasio, Anna Maria Giuliani, Cristina Tung, Spencer Vinters, Harry V Franceschi, Claudio Aging Cell Original Articles Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10(−14)). BlackWell Publishing Ltd 2015-06 2015-02-09 /pmc/articles/PMC4406678/ /pubmed/25678027 http://dx.doi.org/10.1111/acel.12325 Text en © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Horvath, Steve
Garagnani, Paolo
Bacalini, Maria Giulia
Pirazzini, Chiara
Salvioli, Stefano
Gentilini, Davide
Di Blasio, Anna Maria
Giuliani, Cristina
Tung, Spencer
Vinters, Harry V
Franceschi, Claudio
Accelerated epigenetic aging in Down syndrome
title Accelerated epigenetic aging in Down syndrome
title_full Accelerated epigenetic aging in Down syndrome
title_fullStr Accelerated epigenetic aging in Down syndrome
title_full_unstemmed Accelerated epigenetic aging in Down syndrome
title_short Accelerated epigenetic aging in Down syndrome
title_sort accelerated epigenetic aging in down syndrome
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406678/
https://www.ncbi.nlm.nih.gov/pubmed/25678027
http://dx.doi.org/10.1111/acel.12325
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