Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

Inclusion of stochastic differential equations in mixed effects models provides means to quantify and distinguish three sources of variability in data. In addition to the two commonly encountered sources, measurement error and interindividual variability, we also consider uncertainty in the dynamica...

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Detalles Bibliográficos
Autores principales: Leander, Jacob, Almquist, Joachim, Ahlström, Christine, Gabrielsson, Johan, Jirstrand, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406960/
https://www.ncbi.nlm.nih.gov/pubmed/25693487
http://dx.doi.org/10.1208/s12248-015-9718-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406960/
https://www.ncbi.nlm.nih.gov/pubmed/25693487
http://dx.doi.org/10.1208/s12248-015-9718-8

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