Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

To investigate the potential added value of intranasal drug administration, preclinical studies to date have typically used the area under the curve (AUC) in brain tissue or cerebrospinal fluid (CSF) compared to plasma following intranasal and intravenous administration to calculate measures of exte...

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Detalles Bibliográficos
Autores principales: Ruigrok, Mitchel J. R., de Lange, Elizabeth C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406961/
https://www.ncbi.nlm.nih.gov/pubmed/25693488
http://dx.doi.org/10.1208/s12248-015-9724-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406961/
https://www.ncbi.nlm.nih.gov/pubmed/25693488
http://dx.doi.org/10.1208/s12248-015-9724-x

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