Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Neuronal accumulation of UBB(+1), a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB(+1) contributes to neuronal dysfunction remains elusive. Here, we show that in brain regions of AD patients with neurofibrillary tangles UBB(+1) co-exists with VMS1, the mitochon...

Descripción completa

Detalles Bibliográficos
Autores principales: Braun, Ralf J., Sommer, Cornelia, Leibiger, Christine, Gentier, Romina J.G., Dumit, Verónica I., Paduch, Katrin, Eisenberg, Tobias, Habernig, Lukas, Trausinger, Gert, Magnes, Christoph, Pieber, Thomas, Sinner, Frank, Dengjel, Jörn, van Leeuwen, Fred W., Kroemer, Guido, Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407011/
https://www.ncbi.nlm.nih.gov/pubmed/25753421
http://dx.doi.org/10.1016/j.celrep.2015.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407011/
https://www.ncbi.nlm.nih.gov/pubmed/25753421
http://dx.doi.org/10.1016/j.celrep.2015.02.009

Ejemplares similares