A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway

CD4(+)CD25(+) regulatory T cells (Tregs) represent a specialized subpopulation of T cells, which are essential for maintaining peripheral tolerance and preventing autoimmunity. The immunomodulatory effects of Tregs depend on their activation status. Here we show that, in contrast to conventional ant...

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Detalles Bibliográficos
Autores principales: Helling, Bianca, König, Martin, Dälken, Benjamin, Engling, Andre, Krömer, Wolfgang, Heim, Katharina, Wallmeier, Holger, Haas, Jürgen, Wildemann, Brigitte, Fritz, Brigitte, Jonuleit, Helmut, Kubach, Jan, Dingermann, Theodor, Radeke, Heinfried H, Osterroth, Frank, Uherek, Christoph, Czeloth, Niklas, Schüttrumpf, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407014/
https://www.ncbi.nlm.nih.gov/pubmed/25512343
http://dx.doi.org/10.1038/icb.2014.102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407014/
https://www.ncbi.nlm.nih.gov/pubmed/25512343
http://dx.doi.org/10.1038/icb.2014.102

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