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A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway
CD4(+)CD25(+) regulatory T cells (Tregs) represent a specialized subpopulation of T cells, which are essential for maintaining peripheral tolerance and preventing autoimmunity. The immunomodulatory effects of Tregs depend on their activation status. Here we show that, in contrast to conventional ant...
Autores principales: | Helling, Bianca, König, Martin, Dälken, Benjamin, Engling, Andre, Krömer, Wolfgang, Heim, Katharina, Wallmeier, Holger, Haas, Jürgen, Wildemann, Brigitte, Fritz, Brigitte, Jonuleit, Helmut, Kubach, Jan, Dingermann, Theodor, Radeke, Heinfried H, Osterroth, Frank, Uherek, Christoph, Czeloth, Niklas, Schüttrumpf, Jörg |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407014/ https://www.ncbi.nlm.nih.gov/pubmed/25512343 http://dx.doi.org/10.1038/icb.2014.102 |
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