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Regulation of System x (c) (−) by Pharmacological Manipulation of Cellular Thiols
The cystine/glutamate exchanger (system x(c) (−)) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, system x(c) (−) can potentially cause excitotoxicity. However, through providing cystine to the cell, it regulates the levels of cellular glutathione (...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407525/ https://www.ncbi.nlm.nih.gov/pubmed/25949770 http://dx.doi.org/10.1155/2015/269371 |