Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14

Ubiquitin-specific protease 14 (USP14) is a major deubiquitinating enzyme and a key determinant of neuromuscular junction (NMJ) structure and function. We have previously reported dramatic ubiquitin depletion in the nervous systems of the USP14-deficient ataxia (ax(J)) mice and demonstrated that tra...

Descripción completa

Detalles Bibliográficos
Autores principales: Vaden, Jada H., Watson, Jennifer A., Howard, Alan D., Chen, Ping-Chung, Wilson, Julie A., Wilson, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407586/
https://www.ncbi.nlm.nih.gov/pubmed/25954152
http://dx.doi.org/10.3389/fnmol.2015.00011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407586/
https://www.ncbi.nlm.nih.gov/pubmed/25954152
http://dx.doi.org/10.3389/fnmol.2015.00011

Ejemplares similares