Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis

We previously established a role for HSP27 as a predictive marker for therapeutic response towards gemcitabine in pancreatic cancer. Here, we investigate the underlying mechanisms of HSP27-mediated gemcitabine sensitivity. Utilizing a pancreatic cancer cell model with stable HSP27 overexpression, ce...

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Detalles Bibliográficos
Autores principales: Guo, Yang, Ziesch, Andreas, Hocke, Sandra, Kampmann, Eric, Ochs, Stephanie, De Toni, Enrico N, Göke, Burkhard, Gallmeier, Eike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407596/
https://www.ncbi.nlm.nih.gov/pubmed/25331547
http://dx.doi.org/10.1111/jcmm.12444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407596/
https://www.ncbi.nlm.nih.gov/pubmed/25331547
http://dx.doi.org/10.1111/jcmm.12444

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