Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopathy in humans. The aim of this study was to determ...

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Detalles Bibliográficos
Autores principales: Koenig, Sara N., Bosse, Kevin M., Nadorlik, Holly A., Lilly, Brenda, Garg, Vidu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407710/
https://www.ncbi.nlm.nih.gov/pubmed/25914885
http://dx.doi.org/10.3390/jcdd2010017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407710/
https://www.ncbi.nlm.nih.gov/pubmed/25914885
http://dx.doi.org/10.3390/jcdd2010017

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