Cargando…

Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopathy in humans. The aim of this study was to determ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koenig, Sara N., Bosse, Kevin M., Nadorlik, Holly A., Lilly, Brenda, Garg, Vidu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407710/ https://www.ncbi.nlm.nih.gov/pubmed/25914885 http://dx.doi.org/10.3390/jcdd2010017

Ejemplares similares

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract
por: Koenig, Sara N., et al.
Publicado: (2016)

Notch1 haploinsufficiency in mice accelerates adipogenesis
por: Yamaguchi, Kazutoshi, et al.
Publicado: (2021)

Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression
por: Sachdeva, Jaspreet, et al.
Publicado: (2017)

Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model
por: Cheng, Jeeyun, et al.
Publicado: (2014)

Heterozygous eNOS Deficient Mice as a Model to Examine the Effects of eNOS Haploinsufficiency on the Cerebral Circulation
por: Didion, Sean P.
Publicado: (2017)

Echocardiographic Evidence of Innate Aortopathy in the Human Intracranial Aneurysm
por: Shin, Yong-Won, et al.
Publicado: (2014)

Luetic aortopathy: Revisited
por: Madke, Bhushan Sevakram, et al.
Publicado: (2010)

MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy
por: Girdauskas, Evaldas, et al.
Publicado: (2018)

The Genetics of Aortopathies in Clinical Cardiology
por: Goyal, Amit, et al.
Publicado: (2017)

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease
por: Acharya, Asha, et al.
Publicado: (2011)

Patients with Bicuspid Aortopathy and Aortic Dilatation
por: Nappi, Francesco, et al.
Publicado: (2022)

Editorial: Aortopathy in congenital heart disease
por: Weismann, Constance G., et al.
Publicado: (2023)

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
por: Majumdar, Uddalak, et al.
Publicado: (2021)

Evidence for aortopathy of the native descending aorta in children with hypoplastic left heart syndrome
por: Voges, Inga, et al.
Publicado: (2015)

miR‐145 transgenic mice develop cardiopulmonary complications leading to postnatal death
por: Thomas, Shelby, et al.
Publicado: (2021)

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice
por: Blackwood, Christopher A., et al.
Publicado: (2020)

Notch2 and Notch3 Function Together to Regulate Vascular Smooth Muscle Development
por: Wang, Qingqing, et al.
Publicado: (2012)

Notch transactivates Rheb to maintain the multipotency of TSC-null cells
por: Cho, Jun-Hung, et al.
Publicado: (2017)

Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy
por: Yassine, Noor M., et al.
Publicado: (2017)

Is Gorlin–Chaudhry–Moss syndrome associated with aortopathy?
por: Legué, Juno, et al.
Publicado: (2020)

Update in Biomolecular and Genetic Bases of Bicuspid Aortopathy
por: Junco-Vicente, Alejandro, et al.
Publicado: (2021)

Importance of bicuspid aortic valve phenotype on aortopathy
por: Girdauskas, Evaldas, et al.
Publicado: (2022)

Aortopathies: From Etiology to the Role of Arterial Stiffness
por: Bonfioli, Giovanni Battista, et al.
Publicado: (2023)

Pregnancy-associated aortopathy and sudden postpartum death
por: Byard, Roger W
Publicado: (2023)

Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model
por: Soto-Navarrete, María Teresa, et al.
Publicado: (2022)

Arterial tortuosity and change with age in young patients with aortopathy
por: Morris, Shaine A, et al.
Publicado: (2015)

Ventricular‐Vascular Coupling in Marfan and Non‐Marfan Aortopathies
por: Loeper, Farina, et al.
Publicado: (2016)

Enlightening the Association between Bicuspid Aortic Valve and Aortopathy
por: Sophocleous, Froso, et al.
Publicado: (2018)

Contemporaneous management of valvular heart disease and aortopathy in aircrew
por: D’Arcy, Joanna L, et al.
Publicado: (2019)

Computerized Tomography Use in Williams–Beuren Syndrome Aortopathy
por: Kalis, Neale Nicola, et al.
Publicado: (2017)

Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies
por: Creamer, Tyler J., et al.
Publicado: (2021)

Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity
por: Fletcher, Alexander J., et al.
Publicado: (2022)

Cardiovascular Imaging in Pregnancy: Valvulopathy, Hypertrophic Cardiomyopathy, and Aortopathy
por: Ismail, Haneen, et al.
Publicado: (2022)

Surgical management of the aortic arch in patients with inherited aortopathy
por: Lucchese, Gianluca, et al.
Publicado: (2022)

An aortopathy dilemma in pregnancy: A rare case report
por: Saeidi, Mahmoud, et al.
Publicado: (2021)

Generation of iPSC line NCHi012-A from a patient with Alagille syndrome and heterozygous pathogenic variant in the JAG1 gene
por: Cunningham, David, et al.
Publicado: (2023)

Tailoring poplar lignin without yield penalty by combining a null and haploinsufficient CINNAMOYL-CoA REDUCTASE2 allele
por: De Meester, Barbara, et al.
Publicado: (2020)

TIMP3 and TIMP1 are risk genes for bicuspid aortic valve and aortopathy in Turner syndrome
por: Corbitt, Holly, et al.
Publicado: (2018)

Homozygous NOTCH3 null mutation and impaired NOTCH3 signaling in recessive early-onset arteriopathy and cavitating leukoencephalopathy
por: Pippucci, Tommaso, et al.
Publicado: (2015)

Inherited aortopathy assessment in bicuspid aortic valve disease relative
por: Bissell, Malenka M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_98ddtrfojpdqvauh5c9upem04o