Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates

The therapeutic management of antibody-mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal degradation provides a novel approach – depleting the b...

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Detalles Bibliográficos
Autores principales: Nixon, Andrew E., Chen, Jie, Sexton, Daniel J., Muruganandam, Arumugam, Bitonti, Alan J., Dumont, Jennifer, Viswanathan, Malini, Martik, Diana, Wassaf, Dina, Mezo, Adam, Wood, Clive R., Biedenkapp, Joseph C., TenHoor, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407741/
https://www.ncbi.nlm.nih.gov/pubmed/25954273
http://dx.doi.org/10.3389/fimmu.2015.00176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407741/
https://www.ncbi.nlm.nih.gov/pubmed/25954273
http://dx.doi.org/10.3389/fimmu.2015.00176

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