PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control

Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic potential of β-cell cAMP-dependent protein kinase (PK...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaihara, Kelly A., Dickson, Lorna M., Ellenbroek, Johanne H., Orr, Caitlin M.D., Layden, Brian T., Wicksteed, Barton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407848/
https://www.ncbi.nlm.nih.gov/pubmed/25475437
http://dx.doi.org/10.2337/db14-1051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407848/
https://www.ncbi.nlm.nih.gov/pubmed/25475437
http://dx.doi.org/10.2337/db14-1051

Ejemplares similares