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PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control

Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic potential of β-cell cAMP-dependent protein kinase (PK...

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Detalles Bibliográficos
Autores principales:	Kaihara, Kelly A., Dickson, Lorna M., Ellenbroek, Johanne H., Orr, Caitlin M.D., Layden, Brian T., Wicksteed, Barton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2015
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407848/ https://www.ncbi.nlm.nih.gov/pubmed/25475437 http://dx.doi.org/10.2337/db14-1051

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